earticle

영어

Gemcitabine (2,2-difluorodeoxycytidine, dFdC) is an effective antitumor agent in the treatment of several solid tumors. However, it has been reported that gemcitabine has problems such as short plasma half-life, rapid metabolism, and low selectivity towards tumor tissue. In this study,
gemcitabine-loaded biodegradable poly(L-lactic acid) (L-PLA) microparticles were prepared by a supercritical fluid process, called aerosol solvent extraction system (ASES). ASES is a supercritical technique based on solvent extraction using supercritical carbon dioxide for the preparation of microparticles and microspheres. The influence of operating parameters
such as temperature, pressure, concentration, CO2 flow rate and solution flow rate on the morphology and characteristics of the microparticles was studied in detail. The drug entrapment efficiency and loading efficiency were determined by HPLC assays. The entrapment efficiency
increased with increasing temperature, concentration and CO2 flow rate. The ASES-processed drug-loaded microparticles showed a relatively high initial burst due to the presence of pores of the microparticles and the poor affinity between gemcitabine and L-PLA.