earticle

논문검색

포스터 발표 : 바이오의약 및 약물전달

Effect of Coaxial Nozzle on the Preparation of Drug-Loaded Polymer Microparticles Using Supercritical CO2

원문정보

Byung-Hyun WON, In-Il JUNG, Gio-Bin LIM, Jong-Hoon RYU

한국생물공학회 한국생물공학회 학술대회 2010 춘계학술대회 및 국제심포지움 2010.04 pp.224-224
피인용수 : 0건 (자료제공 : 네이버학술정보)

초록

영어

In this study, gemcitabine-loaded poly(L-lactic acid) (L-PLA) nano- and microparticles were prepared using solution enhanced dispersion by supercritical fluids (SEDS) technique. Gemcitabine is a synthetic pyrimidine nucleoside analogue with a high antitumor efficacy for ovarian, breast bladder, and pancreatic cancer. The SEDS process is a modified supercritical
antisolvent (SAS) process, in which supercritical CO2 and polymer/drug solution are simultaneously introduced into a high-pressure vessel using a coaxial nozzle. The effects of CO2 flowrate, solution flowrate, temperature, pressure, polymer molecular weight and solution concentration on the morphology and drug entrapment efficiency of SEDS-processed particles
were investigated. The entrapment efficiency and in vitro release profiles of gemcitabine from microparticles were also determined using HPLC. Our study was focused on the comparison of SEDS with ASES process.

키워드

저자정보

  • Byung-Hyun WON Dept. of Chemical of Biochemical Engineering, The University of Suwon, Gyeonggi-do, Korea.
  • In-Il JUNG Dept. of Chemical Engineering, Yonsei University, Seoul, Korea.
  • Gio-Bin LIM Dept. of Chemical of Biochemical Engineering, The University of Suwon, Gyeonggi-do, Korea.
  • Jong-Hoon RYU Dept. of Chemical of Biochemical Engineering, The University of Suwon, Gyeonggi-do, Korea.

참고문헌

자료제공 : 네이버학술정보

    함께 이용한 논문

      ※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.

      0개의 논문이 장바구니에 담겼습니다.