earticle

영어

Synthesis and characterization of nanocrystalline trivalent silver polydiguanide complex was described. The antibacterial activity of the synthesized nanoparticles was evaluated against burn wound pathogens. Synthesis of essentially monodispersed nanoparticles of higher valent
metal complex was accomplished by oxidation of the monovalent silver, followed by stabilization of the oxidized higher-valent metal through complexation with chlorhexidine, a polydiguanide ligand in a reverse microemulsion at room temperature. Their antibacterial potencies were
assessed invitroby determining the MICs and MBCs against four Gram-positive and four Gram-negative bacteria using agar dilution and microdilution methods. The synthesized nanoparticles showed strong antibacterial activity against the tested Gram (+)/(-) and methicillinresistant
Stahylococcusaureus (MRSA) strains. The minimal inhibitory concentrations (MICs) of the synthesized complex were much lower than those of the ligand, AgNO3, and the gold standard, silver sulfadiazine. These nanoparticles may serve as a new generation antibacterial
metallopharmaceutical in wound care.