원문정보
초록
영어
GABA(γ-amino butyric acid) is one of the major inhibitory neurotransmitters in CNS(central nervous system). Imbalance of GABA and excitatory neurotransmitter can trigger nervous system disorders. Among the nervous system disorders, Parkinson’s disease which slows down the activity of nerve cells is related to GABA. For this reason, highly sensitive and
label free sensor was produced for the detection of GABA as biomarker of Parkinson’s disease. First, by using UV nano imprint lithography, 100 nm wide silicon nanowire was fabricated and verified by SEM (Scanning Electron Microscopy). Second, the electrical sensing capability of the
fabricated silicon nanowire was confirmed by semiconductor parameter analyzer. Third, the antibody against GABA was immobilized on silicon nanowire by self assembly method. Finally, GABA was applied for the detection ; the conductance change of the silicon nanowire sensor was
measured through semiconductor parameter analyzer. Consequently, proposed system could be applied to develop the highly sensitive and selective biosensor and biochips.