earticle

영어

In the last two decades, ordered nanostructures on the solid surface have generated considerable interests owing to their unique electronic, optical, and biological characteristics. In the present work, Zinc selenide (ZnSe) nanocrystals were synthesized in the cavity of the apoferritin from horse spleen (HsAFr), and the two-dimensional ZnSe-ferritin nanodots were
prepared on modified silicon surface. The arrays on the silicon surface provided the PL emission peak for ZnSe quantum dots in ferritin core. In addition, some neurotransmitters can be conjugated to the arrays and the PL spectrum changes accompanying by the conjugation reaction, the fluorescence intensity of ZnSe quantum dots in ferritin core was investigated. It was found that the intensity was dependent on the concentration of the neurotransmitter. When the array was conjugated with GABA, a significant enhancement of the fluorescence occurred and
the enhancement factor was a linear function of the GABA concentration despite the presence of glutamic acid. In reality, it was found that the two-dimensional ZnSe-ferritin nanodot array could be a potential sensor media for GABA detection. This approach is superior to the old method
to measure neurotransmitters in vivo which is complicated by the low concentration of neurotransmitters and suffers from overlapping resonance signals by other substances.