earticle

영어

Cordyceps sinensis is one of the most valued herbs in traditional chinese medicine. The anti-hyperglycemic activiity of the exopolysaccharides (EPS) produced from submerged mycelial culture of Cordyceps sinensis (Cs) was studied in a type II diabetic animal model (C57BL/6J ob/ob). This study was designed to determine whether EPS improves clinical signs of type II diabetes in ob/ob mice. After treatment of ob/ob mice with Cs-EPS at doses of 200 mg/kg body weight, the fasting blood glucose levels decreased by 47% after 63 days. The results of oral glucose tolerance test (OGTT) showed that the glucose levels returned approximately to
baseline after 120 min in EPS-treated mice. Furthermore, food intake, body weight, total plasma cholesterol and triglyceride concentrations in ob/ob mice treated with EPS were significantly decreased. Plasma insulin concentrations were significantly increased by EPS treatment. In addition, we investigated the expression pattern of leptin with important effects in regulating body weight, metabolism and reproductive function. It was reveled that Leptin mRNA was expressed in adipose tissue from EPS-treated ob/ob mice. Immunoblot analysis revealed that the EPS increased the expression of leptin in adipose tissue and plasma. These results indicated that use of these compounds should be considered as a dietary supplement to control hyperglycemia in patients with type II diabetes.