earticle

영어

Recent development on particle design from polymers using supercritical fluids have been reviewed with an emphasis on articles published. A brief description of the basic operating principles of the various particle design processes is presented. These include the rapid expansion of supercritical solutions (RESS), the gas antisolvent process (GAS), supercritical
antisolvent process (SAS) and its various modifications, and the particles from gas-saturated solution (PGSS) processes. This study was performed by PGSS process using supercritical carbon dioxide (SCO2). The PGSS was applied, in a continuous operated pilot plant, for the particle formation of the phosphatidylcholine and phosphatidyl ethanolamine. The particle
formation of phospholipids with biodegradable polymer, polyethelene glycol (PEG) was performed by SCO2 in a thermostated stirred vessel. PGSS were carried out in temperatures ranging from 40 to 50°C and pressures ranging from 20 to 25 MPa to measure the optimum condition for the formation of phospholipid particle. The average diameter of functional
particles was about 0.8-1.4 μm however the average diameter of unprocessed particles was 430 μm. Particles obtained as a function of the CO2 concentration, showed completely solid, spherical-hollow and aggregated particles. The average size of phospholipid particles were
decreased with increasing concentration of CO2. At higher temperature and pressure PEG contained higher amount of phospholipid. The recovery of phospholipid as particle with PEG was very high.