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영어
In this study, the effects of glucosamin derivatives (glucosamine-6-phosphate: PGlc and glucosamine-6-sulfate: SGlc) on osteoblastic cell differentiation were evaluated in osteoblastic MG-63 cells. Our results provided evidences that glucosamin derivatives (PGlc and SGlc) have
the ability to increase the alkaline phosphatase (ALP) activity, the osteocalcin (OC) level and the collagen level as phenotypic markers during osteoblastic differentiation. M oreover, the effect on BMP-2 activity, which is an important factor for bone formation, remodeling and mineralization, was examined by using ELISA, RT-PCR and western blot analysis. Treatment of osteoblastic cells with glucosamin derivatives (PGlc and SGlc) enhanced BMP-2 activity. The present study may provide new insights to the role of glucosamin derivatives in the osteoblastic differentiation and possibility for its application as a supplement in bone health.