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포스터 발표 : 식품 및 바이오신소재

Anti-Inflammatory Effects of Crude Extract and Fractions from Ecklonia cava

원문정보

Jinhyeok LEE, Haejin KIM, Jung Im LEE, Myoung Eun JUNG, You Ah KIM, Chang-Suk KONG, Youngwan SEO

한국생물공학회 한국생물공학회 학술대회 2010 춘계학술대회 및 국제심포지움 2010.04 pp.161-161
피인용수 : 0건 (자료제공 : 네이버학술정보)

초록

영어

In this study, anti-inflammatory effects of crude extracts from Ecklonia cava and their solvent fractions were evaluated using several different activity tests, including degree of occurrence of intracellular reactive oxygen species (ROS), nitric oxide (NO), mRNA expressions of cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) in LPS-activated mouse macrophage Raw 264.7 cells. The levels of intracellular ROS were measured using 2',7'-dichlorofluorescin diacetate (DCF-DA) as fluorescence probe. The generation of NO products was determined based on the Griess reaction. All of them not only exhibited the significant scavenging activity on the generation of ROS but also inhibited LPS-induced NO production without a notable cytotoxicity in Raw 264.7 cells. In addition, they suppressed the mRNA
expression of iNOS and COX-2 in LPS-activated Raw 264.7 cells. Among them, n-buthanol fraction, having high polyphenol content, exhibited the strongest anti-inflammatory effects. Therefore, these results suggest that novel anti-inflammatory compounds can be isolated from
E. cava.

키워드

저자정보

  • Jinhyeok LEE Division of Marine Environment & Bioscience, Korea Maritime University, Busan 606-791, Korea.
  • Haejin KIM Division of Marine Environment & Bioscience, Korea Maritime University, Busan 606-791, Korea.
  • Jung Im LEE Division of Marine Environment & Bioscience, Korea Maritime University, Busan 606-791, Korea.
  • Myoung Eun JUNG Division of Marine Environment & Bioscience, Korea Maritime University, Busan 606-791, Korea.
  • You Ah KIM Division of Marine Environment & Bioscience, Korea Maritime University, Busan 606-791, Korea.
  • Chang-Suk KONG Marine Bioprocess Research Center, Pukyong National University, Busan 608-737, Maritime University, Busan 606-791, Korea.
  • Youngwan SEO Division of Marine Environment & Bioscience, Korea Maritime University, Busan 606-791, Korea.

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