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The Regulatory Role of Visfatin in Neuronal Differentiation and Neuroprotection through Activation of Vigin Signaling Pathway

원문정보

Young-Soon KANG, Jee-Young KIM, Hyun-Joo PARK, Sun-young PARK, Moon-Kyoung BAE, Soo-Kyung BAE

한국생물공학회 한국생물공학회 학술대회 2010 춘계학술대회 및 국제심포지움 2010.04 pp.155-155
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초록

영어

We investigated whether visfatin gene expression, upregulated by hypoxia in cancer cells1), was associated with differentiation of neuronal cells. RT-PCR analysis, morphological observations, and immunostaining revealed that CoCl2, a hypoxic mimetic agent, at 75 microM increased
expression of the visfatin gene, and induced neurite outgrowth in PC-12 rat pheochromocytoma cells2). Visfatin not only induced neurite outgrowth but also significantly upregulated Vigin (visfatin - inducible gene in neuritogenesis) mRNA levels. Therefore, considering that vigin has
been known to be essential for neurite outgrowth and neuroprotective effect, our present results suggest that visfatin-mediated vigin signaling pathway may play important roles in neuritogenesis and neuroprotection.
1) Bae SK, Kim SR, et. al. Hypoxic induction of human visfatin gene is directly mediated by hypoxia-inducible factor-1(2006), FEBS Letters, 580, 4105-4113.
2) Eiichi KN, et. al. Cobalt Chloride Induces Neurite Outgrowth in Rat heochromocytoma PC-12 Cells Through Regulation of Endothelin-2/Vasoactive Intestinal Contractor(2005), Journal of Neuroscience Research, 81, 563-571.

키워드

저자정보

  • Young-Soon KANG Department of Physiology, School of Medicine, Medical Research Center for Ischemic Tissue Regeneration, Pusan National University Medical Science Education Center (BK21 Program), Pusan National University, Yangsan, 626-770, South Korea.
  • Jee-Young KIM Department of Physiology, School of Medicine, Medical Research Center for Ischemic Tissue Regeneration, Pusan National University Medical Science Education Center (BK21 Program), Pusan National University, Yangsan, 626-770, South Korea.
  • Hyun-Joo PARK Department of Oral Physiology, School of Dentistry, Pusan National University, Yangsan, 626-770, South Korea.
  • Sun-young PARK Department of Physiology, School of Medicine, Medical Research Center for Ischemic Tissue Regeneration, Pusan National University Medical Science Education Center (BK21 Program), Pusan National University, Yangsan, 626-770, South Korea.
  • Moon-Kyoung BAE Department of Oral Physiology, School of Dentistry, Pusan National University, Yangsan, 626-770, South Korea.
  • Soo-Kyung BAE Department of Physiology, School of Medicine, Medical Research Center for Ischemic Tissue Regeneration, Pusan National University Medical Science Education Center (BK21 Program), Pusan National University, Yangsan, 626-770, South Korea.

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