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영어
Previous studies suggested that p38 MAP kinase inhibition can suppress the glial cell activation. This study demonstrated that NADPH oxidase activity is essential for inflammogen-mediated induction of reactive oxygen species (ROS) and iNOS expression in murine N9 microglial
cells. The NADPH oxidase inhibitor, diphenyleneiodonium chloride, blocked lipopolysaccharide (LPS)-induced nitric oxide (NO) production in parallel with inhibition of NADPH oxidase activity. Of interest, p38 MAP kinase inhibition suppressed both NO production and NADPH oxidase activity which were induced by LPS. In addition, this study revealed that quercetin, a bioactive phenolic compound known to inhibit oxidative stress and inflammation in macrophage, significantly attenuates microglial production of NO and ROS, a product of NADPH oxidase in
response to LPS treatment. Furthermore, quercetin inhibited p38 MAP kinase activation induced by LPS in microglia. These results suggest that quercetin may inhibit LPS-induced microglia activation through inhibition of p38 MAP kinase.