earticle

영어

Yeast has been studied extensively as a model system for higher eukaryotic organisms, including Homo sapiens and has contributed greatly towards a better understanding of higher eukaryotic cellular functions. The fission yeast Schizosaccharomyces pombe, is an attractive system as a model due to the similarity in cell division with mammals, fission as opposed to
budding, which is used in the more characterized yeast Saccharomyces cerevisiae. Additionally, S. pombe possesses genes that are similar to genes that are found in humans that are responsible for a number of genetic diseases. Here we have reconstructed the genome-scale metabolic model of the fission yeast S. pombe to serve as a platform for better
understanding the metabolic phenotype of S. pombe, and other eukaryotic systems. [This work was supported by the Korean Systems Biology Research Project (20090065571) of the Ministry of Education, Science and Technology (MEST) through the National Research Foundation of Korea (NRF). Further supports by the World Class University Program (R32-2008-000-10142-0) of the MEST, LG Chem Chair Professorship, IBM SUR program, and Microsoft are appreciated.]