earticle

영어

Osteoblastic bone formation (bone remodeling) is a coupled process where bone resorption is normally followed by new bone formation. During some pathological processes in osteoporotic patients, bone remodeling is uncoupled, and bone resorption is not followed by new bone formation. In this study, naringin and lipoic acid was enzymatically esterified by catalyzing with lipase (Novozym 435) in 2-methyl-2-buthanol, to get naringin derivative having lipoic acid at 6-position of its glucose moiety. The chemical structure was characterized by NMR and Mass spectroscopy. The synthesized naringin lipoate significantly enhanced alkaline phosphatase activity, osteocalcin level and matrix protein synthesis in osteoblast like cells. Moreover, naringin lipoate increased bone morphogenic protein synthesis in a dose-dependant manner. Therefore, this result suggests that naringin lipoatecan be used as a nutraceutical and a drug for osteoporosis and related symptoms.