earticle

영어

Gamma aminobutyric acid (GABA) is the non-essential amino acid not found in natural proteins and is found in the human brain and eyes. It serves as a major inhibitory neurotransmitter with hypertensive and diuretic effects in animals. GABA has been applied in health functional foods, which may promote relaxation and relieve nervous tension. Recently, bio-based fuels and polymers have become important due to the increase of oil price and concerns about environmental pollution. Because GABA is the possible monomer for nylon 4, which is the
biodegradable heat-resistant polymer, production of GABA from cheap carbon source such as L-glutamate (MSG) become important in an industrial point of view. Several Lactobacillus strains have been reported to convert L-glutamate to GABA through α-decarboxylation of L-glutamate
catalyzed by pyridoxal phosphate-dependent glutamate decarboxylase. In this presentation, we report whole cell reaction for the production of GABA from L-glutamate using various Lactobacillus strains. Reaction conditions affecting GABA production including temperature, pH, and initial L-glutamate concentration were examined