earticle

영어

Pradimicins, produced by Actinomadura hibisca P157-2, are potent antifungal polyketide antibiotics having an unusual dihydrobenzo [α]naphthacenequinone aglycone substituted with D-alanine and sugars. The compound is generated by type II PKS. Since acetyl-CoA is the
precursor for the biosynthesis of pradimicin, we tried to enhance pradimicin production in the wild strain, by supplying excess biosynthetic precursors. So, a gene complex for acetyl-CoA carboxylase (ACCase) which catalyzes the carboxylation of acetyl-CoA to produce malonyl-CoA was overexpressed in Actinomadura hibisca P157-2 in order to maximize pradimicin
production.