원문정보
초록
영어
Surface plasmon resonance (SPR) is one of the most versatile techniques for the observation of biochemical interactions such as antigen-antibody bindings. In principle, SPR is highly sensitive to changes in the refractive index close to metal surfaces. Therefore, one can sensitively detect the binding of biochemical molecules to the surface without any labels in real time. Gold surface-based SPR has been used to detect diverse biological substances (e.g., proteins, DNA, small organic molecules, toxins and viruses) for a wide range of applications (e.g., drug screening,
disease immunoassays, process control, and environmental monitoring). So, we had a good technology transfer from KRIBB to commercialize about a palm-sized SPR sensor using rotating mirror system. In this system, the beam from a diode laser (as the incident light source) is modulated using a rotating mirror, and a part of the reflected light that diverges from the centre of the rotating mirror is focused on the gold surface. The reflected light from the gold chip is then captured using a CMOS image sensor controlled by a notebook PC via a USB interface. This provides a portable SPR sensor device for POCT via label-free and real-time analyses that it
can be put to practical use in the on-site field detection of a variety of substances that are of interest to biology, diagnosis, the environment, and defense.