원문정보
초록
영어
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Yet, elucidation of molecular pathogenesis of HCC development is still limited, and therefore, new developments to identify important prognostic factors and novel molecular targets of HCC are greatly needed. Our study was conducted to characterize gene expression profile of prognosis in patients with liver cancer by real-time reverse-transcription PCR (RT-PCR). The gene expression levels were obtained from of 128 primary HCCs and 40 non-cancerous surrounding livers. Several risk genes and survival genes were identified which showed significant deregulation in HCC tissues compared to noncancerous surrounding tissues. The expression levels of these genes were independent prognostic factors for overall survival (OS) time in HCC patients. Subsequently, the significant gene signature was validated in an independent cohort of 231 patients from three institutions, in which high risk score was significantly correlated with shorter overall survival (P = 0.00011). In conclusion, we suggest that the proposed gene signature may improve the prediction accuracy for survival of hepatocellular carcinoma patients, and complement prognostic essment based on important clinicopathologic parameters such as tumor stage.