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Tissue Engineering and Stem Cells Symposium - 좌장 : 김병수(서울대)

Synthesis of in situ hydrogels and its applications in bone tissue engineering

원문정보

Insup NOH, Seong Yeon JO, Do-Yeon KIM, Sumi KIM, Jung-Hoon WOO, Yongdoo PARK, Kyu-Back LEE, In-Sook KIM, Soon-Jung HWANG

한국생물공학회 한국생물공학회 학술대회 2010 춘계학술대회 및 국제심포지움 2010.04 pp.86-86
피인용수 : 0건 (자료제공 : 네이버학술정보)

초록

영어

Tissue engineering is a medical technology intended to replace or regenerate the damaged or lost tissue or organs by utilizing three elements of cells, biological/physical signals and a scaffold, Regenerations of bones, vessels, cartilages, bladders and skins have been reported to be successful in clinical by employing tissue engineering technology, We developed a new scaffold for its application in tissue engineering by employing biocompatible polymers such
as hyaluronic acid, chondroitin sulfate and poly(ethylene oxide). Bone tissue engineering has been tried by employing glycosaminoglycan based hydrogel as a scaffold. The hydrogel has been fabricated through in situ Michael type addition reaction between acrylate of hyaluronic acid and thiols of poly (ethylene oxide). After characterization of derivatives of hyaluronic acid
and poly(ethylene oxide) with various analytical tools such as FTIR, NMR, XPS, the synthesized hydrogel was evaluated for its application in tissue engineering. Swelling behaviors, gel formation, compression test were performed for its physical evaluations. In vitro tests such as cell viability, cell toxicity have shown its excellent biocompatibilty. In vivo in rat calvarial defect model demonstrated induction of bone tissue formation over several weeks. Analysis of the regenerated bone was performed with histological methods.

키워드

저자정보

  • Insup NOH Dept. of Chemical Engineering, Seoul National University of Technology, Seoul, 139-743.
  • Seong Yeon JO Dept. of Chemical Engineering, Seoul National University of Technology, Seoul, 139-743.
  • Do-Yeon KIM Dept. of Chemical Engineering, Seoul National University of Technology, Seoul, 139-743.
  • Sumi KIM Dept. of Chemical Engineering, Seoul National University of Technology, Seoul, 139-743.
  • Jung-Hoon WOO Dept. of Chemical Engineering, Seoul National University of Technology, Seoul, 139-743.
  • Yongdoo PARK Department of Biomedical Engineering, College of Medicine, Korea University, Seoul.
  • Kyu-Back LEE Department of Biomedical Engineering, College of Medicine, Korea University, Seoul.
  • In-Sook KIM College of Dentistry, Seoul National University, Seoul.
  • Soon-Jung HWANG College of Dentistry, Seoul National University, Seoul.

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자료제공 : 네이버학술정보

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