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영어

Stem cells have been widely studied as a powerful source for cell therapy because of their high self-renewal activity and high telomerase activity that may provide an unlimited supply of target cells. Despite the clinical prospect, it is necessary that several problems be resolved prior to
clinical application. For example, establishment of clinical grade stem cells, efficient differentiation toward specific cell lines, functional recovery, and regulation of immune rejection are all pressing issues in the field. Recently we have not only developed a novel culture technique using porous membranes for human embryonic stem cell (hESC) expansion[1],
but also shown the neovascularization[2] and bone formation[3] potential of hESCs in vivo using a mouse model. Herein, I will present my recent studies about more improved culture technique as well as therapeutic effect of stem cell using scaffold[4] and gene delivery system[5] for
clinical applications. These studies would provide critical platform to address the clinical application of stem cells in the future of regenerative medicine.