earticle

영어

Chinese hamster ovary (CHO) cells are currently the most important host cells for the production of therapeutic proteins and antibodies. For past ten years there have been revolutionary advances in protein production technologies using CHO cells, and thus the present cost for
protein production using CHO cells has become competitive to that using microbial systems. There are many points to be considered to develop efficient production process of antibodies. Among these, the recent advances in establishing stable production CHO cell lines, cultivation process, and cell engineering for better post-translational modifications of proteins will be discussed in detail with some case studies in my laboratory.