원문정보
초록
영어
All steps of developing anti-cancer therapeutics are exposed to high-risk of failure. However, optimal pre-clinical translational research using proper animal models would reduce the risk and additionally provide rational-based prediction of following clinical challenges. To realize the
optimal pre-clinical translational research, we are constructing a library of patient-derived cancer cells including information about their chromosomal alterations, gene expressional characteristics, and clinical prognosis of patients from which cells oriented. Orthotopic animal
models of various kinds of cancers are also being established using cancer cells from the library, which would provide proper animal models that mimic the cancers of patients closely. Since we could provide a hospital based personalized drug discovery platform with the
library and orthotopic animal models, personalized translational research closer to the bedside for various anti-cancer therapeutics could be serviced to many researchers and pharmaceutical companies.