원문정보
초록
영어
The effect of circadian rhythm on gentamicin pharmacokinetics was studied in rabbits who took a single intravenous 2 mg/kg dose of gentamicin at 09:00 in the morning (a.m.) and 22:00 in the evening (p.m.). A significant circadian rhythm of pharmacokinetic parameters as a function of time of day was noted in rabbits, showing lower total body clearance and higher serum area under the curve (AUC) when given in the evening. The half-life was shorter in the morning when compared to the evening . The AUC was greater in the evening than that in the morning , most likely because the CLt was significantly higher when gentamicin was given in the morning versus in the evening . The of gentamicin in the evening was increased significantly(p<0.05) compared to those of gentamicin in the morning. It is reasonable to consider individual circadian rhythm for effective dosage regimen of gentamicin in clinical chronotherapeutics.