원문정보
초록
영어
This study was conducted to investigate the anti-diabetic activity of Kocat-D1, which is widely used in traditional medicine to treat diabetes in Shandong, China. Sprague Dawley rats (8 weeks of age) were separated into 4 groups: a normal control, streptozotocin (STZ)-induced diabetic rat group (DM control), Kocat-D1-1 (diabetic rat treated with 0.25 g/kg/day hot water extract), and Kocat-D1-2 (diabetic rat treated with 1 g/kg/day hot water extract). After eight weeks of treatment, the fasting blood glucose levels of the Kocat-D1-1 (334.3±32.9 mg/dL) and Kocat-D1-2 group (259.5±35.0 mg/dL) were significantly lower when compared to the DM control group (451±42.6 mg/dL). Furthermore, the levels of glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), albumin and high-density lipoprotein (HDL) cholesterol in the serum of the Kocat-D1-2 group were significantly normalized when compared to the DM control group. However, significant differences were not observed between the Kocat-D1-1 group and the DM control group. Histochemical staining of the liver of the Kocat-D1-2 group revealed no fat accumulation. The insulin level was significantly upregulated in the Kocat-D1-2 group (0.13±0.02 ng/mL) when compared to the DM control group (0.05±0.04 ng/mL). The relative volume of β-cells in the pancreas of the Kocat-D1-2 group (49.4±4.2%) also increased significantly when compared to the DM control group (12.9±7.9%). These results suggest that Kocat-D1 exerts an anti-hyperglycemic effect through the enhancement of insulin secretion.
목차
서론
재료 및 방법
시료의 조제
실험동
실험동물
당뇨유발 및 실험군 구성
체중, 식이, 음수량 및 혈당측정
당부하 검사(Oral Glucose Tolerance Test: OGTT)
혈장의 생화학적 분석
광학 현미경 관찰
통계처리
결과 및 고찰
체중, 식이 및 음수량 측정
혈당 변화 및 당부하 검사
혈장의 생화학적 분석 및 조직학적 분석
혈액 중 인슐린 농도 및 췌장의 변화
요약
문헌