earticle

영어

The α-MSH antagonists prevent the synthesis of melanin resulting in reducing the formation of unwanted pigmentation and making the skin bright. In this study, we have developed the intelligent delivery system for the nonapeptide (Met-Pro-D-Phe-Arg-D-Try-Phe-Lys-Pro-Val-
NH2) as a α-MSH antagonist, the pH-sensitive P(MAA-co-EGMA) hydrogel microparticles were prepared and their feasibility for the intelligent delivery carries was evaluated. The loading efficiency of nonapeptide at pH 7.0 increased as the amount of MAA in the hydrogel increased. The P(MAA-co-EGMA) hydrogel microparticles showed a pH-sensitive release behavior. At low pH (pH 4.0) small amounts of nonapeptide were released from the particles while at high
pH (pH 6.0) relatively large amounts of nonapeptide were released from the particles. In addition, at pH 4.0 a very little amount of nonapeptide was permeated through the skin while at pH 6.0 relatively high skin permeability was obtained. For the treatment of the nonapeptide with pepsin, the hydrogel microparticles showed the protective ability for the nonapeptide and keep the stability of the nonapeptide.