원문정보
초록
영어
In this study, crosslinking of PVA based hydrogels were performed with radiation processing technology using a Co-60 gamma source and followed by freeze-thawing (FT). The influence of time, concentration and dose on hydration and gelation of the hydrogel treated in different
conditions such as oven-dry (OD), room-dry (RD) and freeze-dry (FD) has been investigated. The hydration of the hydrogels increased rapidly with time for first 48 h, and then become nearly constant in the range 48–120 h. The prepared hydrogels at lower concentrations and doses exhibit higher values of hydration but they represent a fall of these values at higher concentrations and doses. These occur mainly as a result of the increase of crosslinking density in the hydrogel by gamma-ray irradiation. Futhermore, FD samples have higher hydration
values as compared with OD and RD samples. Considering this, the quality control of hydrogels for biomedical applications could be achieved to some extent by employing various processing conditions.