earticle

영어

The purpose of this study is to prepare gemcitabine-loaded poly(Llactic acid) (L-PLA) nano- and microparticles using solution enhanced dispersion by supercritical fluids (SEDS) technique. Gemcitabine is a synthetic pyrimidine nucleoside analogue with a high antitumor efficacy for ovarian, breast bladder, and pancreatic cancer. The SEDS process is a modified supercritical antisolvent (SAS) process, in which supercritical CO2 and polymer/drug solution are simultaneously introduced into a high-pressure vessel using a specially designed coaxial nozzle. The effects of temperatures, pressures, polymer molecular weight and solution concentrations on the morphology and drug entrapment efficiency of SEDS-processed particles were investigated. Our study was focused on the comparison of SEDS with ASES process.