earticle

영어

Poly(ethylene glycol)-polyester block copolymers have widely been used in biomedical and pharmaceutical fields because of their excellent biocompatibility, biodegradability, and amphiphilicity arising from phase-separated microstructures between a hydrophilic PEG block and a hydrophobic polyester block. The aims of this research are to prepare gemcitabine-loaded microparticles using methoxy poly(ethylene glycol)-poly(L-lactide) (mPEG-PLLA) diblock copolymer and to evaluate their release characteristics. We synthesized mPEG-PLLA
diblock copolymers of different block lengths, and their molecular compositions and molecular weight were analyzed by 1H-NMR and GPC. W/O/W double emulsion solvent evaporation method was used to prepare gemcitabine-loaded mPEG-PLLA microparticles. The effects
of various preparative parameters such as pH, salt concentration of external water phase, solvent composition of organic phase and ratio of internal/external water phase on the morphology and the encapsulation efficiency of the microparticles were investigated. The in vitro release
profiles of gemcitabine from microparticles were also determined using HPLC.