원문정보
초록
영어
Photodynamic therapy (PDT) is a promising method for the treatment of several diseases including cancer. It involves the systemic administration of photosensitizers(PSs) such as porphyrin, followed by local photoirradiation with the light of a specific wavelength.[1] In this work, a 3rd generation dendrimer porphyrin (DP Mw ~8,000 g/mol) with 32 carboxyl groups
on the periphery was used as a component to prepare a layer-by-layer (LbL) structure via an electrostatic adsorption using its anionic peripheral groups.[2] To enhance the efficacy and tumor-specificity of PDT, poly(allylamine hydro chloride) (PAH, Mw ~50,000 g/mol) / DP
nanocarrier was constructed through a LbL self-assembly of PAH and DP on a removable template. It has been reported that the optimal size of drug carriers for efficient delivery of an antitumor agent to a tumor is round 100-200 nm. We chose the monodispersed polystyrene
nanoparticles with a diameter of 100 nm which can be dissolved in chloroform.[3] The anticancer drug could be encapsulated into the nanocarriers and its release from hollow polyelectrolyte nanocarriers can be controlled by changes of membrane permeability, which
respond to stimulus such as pH.