earticle

영어

An experiment was carried out to compare wound healing processes from the porcine skinderived and human-derived wound dressings. A common treatment of wounds is wound
dressing derived from human cadaver skins which were distributed by approved tissue banks. The wound dressings are processed for hospital uses under the strict guidelines. The supply of human skins is limited. Therefore, we examined possibility of an alternative source of processed wound dressing derived from porcine skin. Porcine skins were procured using Dermatome (Zimmer Inc.) and manufacturing process was followed as human cadaver skin (Hans Biomed Procedures). Final dressing and intermittent processing materials were examined to compare with human skin in physical and biochemical properties. And a beagle dog was used in vivo experiment, induced wounds and applied dressing materials from both porcine and human. Structural and physical properties of the two skin dressings were showed similar by SEM, histological analysis, IHC, tensile strength, collagenase decomposition and GAGs assay. Also in an animal experiment, wound healings were taking place about the same degree of contraction and epithelialization whether porcine or human originated materials applied. In conclusion, porcine skin-derived dressing may be found to have equivalent efficacy and effects as the human skin-derived. We suggest that wound dressing derived from porcine skin can be used, when human skinderived dressings are not available and manufactured under the proper guideline.