원문정보
초록
영어
1,3-propanediol (1,3-PD) is of commercial attention as an important monomer to synthesize a new type of polyester, polytrimethylene terephthalate (PTT) which has excellent properties in textile and fiber industries. Klebsiella pneumoniae is an excellent 1,3-PD producer, but the simultaneous production of many by-products (2,3-butandiol, Ethanol, Succinic acid, etc.) have greatly reduced the fermentation efficiency of 1,3-PD. Recently we engineered mutant strains of K. pneumoniae to eliminate the formation of by-products hindering the downstream process, typically 2,3-butanediol, during the production of 1,3-propanediol (1,3-PD) from glycerol by inactivating the oxidative branch of the glycerol metabolic pathway. Although the by-product formation was successfully eliminated, production yield and productivity of 1,3-PD was severely
diminished in the mutant strains. This study presents optimization of medium component to improve the 1,3-PD production using the recombinant strain defective of the glycerol oxidative pathway eliminating by-product formation