원문정보
초록
영어
1,3-propanediol (1,3-PD) is of commercial attention as an important monomer to synthesize a new type of polyester, polytrimethylene terephthalate (PTT) which has excellent properties in textile and fiber industries. Kebsiella pneumoniae is an excellent 1,3-PD producer, but
the simultaneous production of many by-products (2,3-butandiol, Ethanol, Succinic acid, etc.) have greatly reduced the fermentation efficiency of 1,3-PD. Hence, to eliminate the by-products synthesis, the oxidative branch of glycerol metabolism was inactivated by deleting the genes involved in the synthesis of by-products from the chromosomal DNA. The present investigation focuses on the effect of the culture conditions on the production of 1,3-PD from glycerol using
the engineered strain. The fermentation parameters, such as pH control, aeration volume and cell concentration, were examined in fermentor-scale experiments.