원문정보
초록
영어
In search for novel bioactive secondary metabolites from salt marsh plants, a number of halophytes were collected in western coastal area of Korea and screened for a series of biological activities. Among the collected halophytes, Whole plants of Vitex rotundifolia were extracted for 2 day with dichloromethane and methanol, respectively. The combined crude extracts were concentrated in vacuo and then fractionated into n-hexane, 85% aq. MeOH, n-BuOH, and water fractions. The antiproliferative effects of the crude extracts and their solvent fractions against HT1080, AGS and HT-29 human cancer cells were compared with the control at the concentrations of 10, 50, and 100 μg/mL by using MTT assay. In the comparative analysis, the 85% aq. MeOH fraction exhibited the strongest antiproliferative effects on human cancer cell lines in a dose-dependent manner (p < 0.05). The growth inhibition rate on HT1080, AGS, HT-29 human cancer cells was 74.0%, 79.9%, and 31.6%, respectively, when the 85% aq. MeOH fraction
(10 μg/mL) was added to them. These results suggested that active compounds having a strong anticancer effect can be isolated from Vitex rotundifolia