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유전자 및 대사공학

Metabolic Pathway Analysis for Production of Succinic Acid in Mannheimia succiniciproducens and Escherichia coli

원문정보

Sang Yup LEE, Tae Yong KIM, Hyung Rok CHOI

한국생물공학회 한국생물공학회 학술대회 2009 추계학술대회 및 국제심포지움 2009.11 pp.189-189
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초록

영어

Mannheimia succiniciproducens MBEL55E is a capnophilic gramnegative bacterium which efficiently produces succinic acid. In order to analyze metabolic pathways of M. succiniciproducens, we applied pathway analysis to the biochemical network of M. succiniciproducens, previously developed by our group. We then also analyzed the biochemical
network of Escherichia coli, in the same way as above, in order to grasp the notable differences between these two organisms. We clustered the solutions of two microorganisms, and compared each other. Each of clusters showed characteristic yield of succinic acid and the number of solutions and clusters of M. succiniciproducens is greater than that of E.coli. [This work was supported by the Genome-based Integrated Bioprocess Project of the Ministry of Education, Science and Technology (No. 2005-01294). Further supports by the LG Chem Chair Professorship, Microsoft, IBM SUR, WCU(World Class University) program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (R32-2008-000-10142-0) are appreciated.]

키워드

저자정보

  • Sang Yup LEE Department of Chemical and Biomolecular Engineering (BK21 Program), Metabolic and Biomolecular Engineering National Research Laboratory, Center for Systems and Synthetic Biotechnology, Institute for the BioCentury, Korea Advanced Institute of Science and Technology, Daejeon 305-701.
  • Tae Yong KIM Department of Chemical and Biomolecular Engineering (BK21 Program), Metabolic and Biomolecular Engineering National Research Laboratory, Center for Systems and Synthetic Biotechnology, Institute for the BioCentury, Korea Advanced Institute of Science and Technology, Daejeon 305-701.
  • Hyung Rok CHOI Department of Chemical and Biomolecular Engineering (BK21 Program), Metabolic and Biomolecular Engineering National Research Laboratory, Center for Systems and Synthetic Biotechnology, Institute for the BioCentury, Korea Advanced Institute of Science and Technology, Daejeon 305-701.

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