earticle

영어

Kinetic models are proposed for the production of succinic acid from glucose by Mannheimia succiniciproducens MBEL55E. Experimental data collected from a series of batch fermentations with different initial glucose concentrations were used to estimate parameters and also to validate the models proposed. The optimal values of the parameters were measured by minimizing the discrepancy between the model predictions and corresponding experimental data. The growth of M. succiniciproducens could be expressed by a modified Monod model incorporating inhibitions of glucose and organic acids accumulated in the culture broth. In all
cases, the model simulation matched well with the experimental observations, which made it possible to elucidate the fermentation characteristics of M. succiniciproducens during succinic acid production from glucose. These models can be employed for the development and optimization of bio-based succinic acid production processes. [This work was supported by the Genome-based Integrated Bioprocess Project of the Ministry of Science and Technology (No. 2005-01294). Further supports by the LG Chem Chair Professorship, Microsoft, IBM SUR,
WCU(World Class University) program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (R32-2008-000-10142-0) are appreciated.]