원문정보
초록
영어
4 kinds of RNPs(Regional Special Natural Products) were used to verify for Anti-obesity effet. In the western blot for 3T3-L1 cell, expression level of PPARγ(peroxisome proliferator-activated receptor γ) was suppressed by different concentraton of 4 RNPs when treated chemical with MDI(IBMX, Dexamethasone, Insulin) at the same time. Also, SREBP-1(Sterol regulatory element binding protein) and PPARγ expression levels were reduced by 4 RNPs in a dose-dependent manner when treated chemicals after differentiation. And adipogenesis was reduced by 7.5%, 14.4%, 18.3% and 30% at different concentration of Anthrisci Radix when performed Oil red O staining. Also, it was reduced by 2%, 4.9%, 9.3% and 38% at different concentration of Psoraleae Semen. When treated with Siegesbeckiae Herba, it was inhibited by 1.4%, 6.4%, 16.4% and
30.1%, respectively. And Corni Fructus was also showed by 0.9%, 6.3%, 13.7% and 33% at same concentration of Siegesbeckiae Herba. As a result, 4 RNPs were expected for a useful material for Anti-obesity and Anti-cancer as well.