earticle

영어

A nanoparticle is a small particle with at least one dimension less than 100 nm. Recently, nanoparticle research attracts public attention due to its potential to be applied to biomedical, optical, and electronic fields. Many scientist and engineer make efforts to develop new
nanomaterials to be effective on illness and disease like cancer beyond current imagination. Polymer-based nanoparticles are designed to improve the property of drugs in terms of pharmacokinetics which determines the strength of drug delivery system. We have recently
found that orally administered nano-size polystyrene beads pass through the pharynx and are taken up into the intestine. When we fed animals with 50, 100, 200, and 500 nm polystyrene beads, only 50 and 100 nm particles were mobilized beyond the gut and were found to
accumulate in the gonad and epidermis. To explore the requirements for nanoparticle transport, we tested uptake of 50 nm particles in worms defective for genes involved in apical transport or endocytosis in intestinal lumen and found which proteins enable nanoparticles to move from the intestine to other sites in the animals. These findings suggest that the upper limit in this size of nanoparticles that can undergo endocytic transport from the lumen to gut and from gut to
other organs may be less than 200 nm.