earticle

영어

Bone marrow stromal cells or MSCs exists as a population of cells having the capacity to differentiate into osteogenic, chondrogenic or adipogenic lineages in vitro and in vivo. To utilize the enormous MSCs potential for cartilage injury repair, numerous attempts have been made, including MSC-seeded scaffold and cultured MSCs implantation in vivo. Formation of biological substitute using the concept of tissue engineering generally requires an artificial scaffold. The
three dimensional environment plays an important role in promoting cell-matrix interactions during chondrogenesis and the phenotypic stability of chondrocytes are closely related to their surrounding 3D matrix. The extracellular matrix (ECM) has received significant attention as a functional scaffold in the tissue engineering field, because it can serve not only a physical support but also provide favorable environments for cells. However, the ECM scaffold still requires
many technical improvements to construct artificial tissue suitable for clinical use. So, we developed a novel ECM scaffold fabricated by our proprietary procedure using cultured chondrocyte and focus on ECM application to clinical use. Until now, we apply that novel ECM scaffold and membrane were developed. And, we demonstrated that ECM would confer benefit as a result of cartilage defect after ECM scaffold or membrane implantation.