earticle

영어

MRC-01 (common name: methiozolin), 5-(2,6-difluoro-benzyloxymethyl)-5-methyl-3-(3-methyl- thiophen-2-yl)-4,5-dihydro-isoxazole, is a new herbicide candidate. This compound belongs to isoxazoline family, but not related to any other commercialized pesticides. MRC-01 has safety to various crops including soybean, wheat, rice, cotton, and turfgrass, and controls certain grass weeds such as barnyardgrass (Echinochloa crusgalli), crabgrass (Digitaria sp.), annual bluegrass (Poa annua), blackgrass (Alopecurus myosuroides) etc by pre or post-emergence application at 250 to 1,000 g/ha. In turf, MRC-01 has a high safety to various cool season turf species including bentgrass and Kentucky bluegrass, and controls the major grass weeds (annual bluegrass and crabgrass). MRC-01 is superior to the commercial standards in post emergence activity. MRC-01 mode of action was shown, by [14C]-glucose incorporation study, to be a strong inhibitory activity in cell wall biosynthesis in maize. Toxicology studies have proven that MRC-01 has a high safety to mammals, fishes, bees, earthworm, and birds etc. The molecule was non-genotoxic and nonteratogenic. Animal metabolism study showed that MRC-01 was readily absorbed in the gastrointestinal tract, rapidly metabolized in the liver, and excreted through bile, faces, and urine. Greater than 90% of the administered was excreted out within 96 h. In rats, numerous minor metabolites were formed and one of the metabolites was identified to be 2-(5-((2,6- difluorobenzyloxy)methyl)-4,5-dihydro-5- methylisoxazol-3-yl)thiophen-3-yl)methanol. In soil, MRC-01 was readily degraded in a non-sterile aerobic condition. In field dissipation studies, DT50 of MRC-01 was about 10 days. Collectively, MRC-01 has a unique fitness as a turf herbicide and favorable toxicology and environmental fate. MRC-01 was applied for registration for turf uses in September 2009 to KRDA, and is in registration trials in Japan.