earticle

영어

A novel disposable bioreactor system utilizing a pneumatic mixing technology has been developed recently (PBS Biotech, Inc.). Since this technology does not require any external mechanical device for liquid agitation, it can offer a simple, compact, and scalable bioreactor
system. Cell culture performance in larger scale units up to 250 L was studied and compared to that of a 300 L stainless steel bioreactor. In addition, 2 L units of this bioreactor system were evaluated to be representative scale-down models that can be used for process development and characterization while maintaining the same mixing mechanism. In this presentation, the new features of this novel disposable bioreactor will be introduced and then the results from
biological tests involving CHO cell lines expressing recombinant monoclonal antibodies will be discussed.