원문정보
초록
영어
This study evaluated the effects of γ-irradiation on immunomodulating properties and structural changes of β-glucan. β- Glucan solutions (10 mg/mL) were γ-irradiated at 10, 30, and 50 kGy. Splenocyte proliferation and cytokine (interferon-γ and interlukin-2) productions by γ-irradiated β-glucan were evaluated in in vivo and in vitro, and structural changes of β-glucan were also determined after γ-irradiation. γ-Irradiation on β-glucan at 50 kGy enhanced splenocyte proliferation and cytokine productions, (p<0.05) and cleft glycosidic bonds of β-glucan resulting in lower the molecular weight. These results indicate that the use of γ- irradiation on β-glucan may be useful for improving its immunological activity by lowering the molecular weight of β-glucan.
목차
Introduction
Materials and Methods
Results and Discussion
References