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Geranium rose oil activate TOP flash. So, we carried out to investigate the effect of these
essential oils on hair growth in a shaving animal model of C57BL/6 mice. The animals were
divided into 3 groups including negative control group (vehicle), positive control group(5%
minoxidil), and experimental group (3% geranium rose) and they were topically applied with an
amount of 100㎕ once a day, every other day for 4 weeks. Hair regrowth was evaluated by
photographical bservations. Topical treatment of Geranium rose oils for 4 weeks to dorsal skin
accelerated hair regrowth faster than vehicle group, as evaluated in photographical observation.
Geranium rose oils groups promoted development and elongation of hair follicles by 115% in
comparison with vehicle group. To investigate the effect of proliferation and differentiation in normal human keratinocytes by Geranium rose oil, we made recombinant adenovirus; expressing luciferase-tagged involucrin promoter. After adenoviral transduction into normal human keratinocytes cultured in vitro, performed luciferase assay to the effect of Geranium rose oil for keratinocyte differentiation. As a result, involucrin promoter activity was slightly increased by Geranium rose oil. Together, our results implicate the potential of Geranium rose oil for hair loss drug and keratinocyte differentiation promoting.