earticle

영어

Antiproliferative activity of the ethanol extract of Atractylodes japonica rhizomes (AJEX) was investigated usingmethyl thiazolyl tetrazolium (MTT) assays with various cancer cell lines (HL-60, MCF-7, SK-Br-3, MDA-MB-453, HepG2,Hep3B, PC-3, LNCaP, MKN 28, MKN 45, and HT-29 cells). Gastric carcinoma cell lines were the most responsive in termsof cell proliferation. The IC50 of MKN 28 and MKN 45 cells were 35.98 and 27.57µg/mL, respectively. Moreover, gastriccarcinoma cells exposed to AJEX underwent apoptosis, as determined by Annexin V binding assay. Compared to respectivecontrol level, exposure to the AJEX at each IC50 concentration resulted in a remarkable increase in the shift of cellpopulations. Present results suggest that AJEX possess potential anticancer properties.