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Effects of perilla leaf extracts (PLE) on adipocytes differentiation of 3T3-L1 cells were examined. Ethanol extractof PLE treatment significantly decreased lipid accumulation, a marker of adipogenesis, in a dose-dependent manner.Moreover, gene expression levels of peroxisome proliferator-activated receptor γ (PPARγ), the key adipogenic transcriptionfactor, were markedly decreased by PLE. PLE also suppressed adipocyte fatty acid binding protein (aP2) and glycerol-3-phosphate dehydrogenase (GPDH), which are adipogenic marker proteins. These results suggest that PLE treatmentsuppressed differentiation of 3T3-L1 adipocytes, in part by down-regulating expression of adipogenic transcription factor andother specific target genes.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
References
Introduction
Materials and Methods
Results and Discussion
References
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자료제공 : 네이버학술정보