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논문검색

Anti-inflammatory Activities of Ethylacetate Extract of Rehmannia glutinosa in LPS-induced RAW 264.7 Cells

원문정보

Chang Hyun Jin, Min Ah Kang, Young Man Lee, Yong Dae Park, Dae Seong Choi, Myung Woo Byun, Il Yun Jeong

한국식품과학회 Food Science and Biotechnology Volume 18 Number 4 2009.08 pp.923-927
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초록

영어

This study is to investigate the anti-inflammatory effects of the ethylacetate extract of Rehmannia glutinosa(RGEAE). The anti-inflammatory activities using nitric oxide (NO), cytokine, and chemokine production in lipopolysaccharide(LPS)-induced RAW 264.7 cells were checked. Results indicated that RGEAE suppressed the NO, interleukin-6 (IL-6), andmonocyte chemoattractant protein-1 (MCP-1) production in a dose-dependent manner. Inhibition of NO formation was due to adecrease in inducible NOS (iNOS) expression. It was also found that the anti-inflammatory activities of RGEAE resulted from itsinhibitory role on the nuclear factor (NF)-κB activation and reactive oxygen species (ROS) production. Therefore, it is suggestedthat RGEAE has potential as a therapeutic material to attenuate the inflammatory disease such as rheumatoid arthritis.

목차

Abstract
 Introduction
 Materials and Methods
 Results and Discussion
 References

키워드

저자정보

  • Chang Hyun Jin Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, Jeonbuk 580-185, Korea
  • Young Man Lee Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561-756, Korea
  • Min Ah Kang Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, Jeonbuk 580-185, Korea
  • Yong Dae Park Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, Jeonbuk 580-185, Korea
  • Dae Seong Choi Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, Jeonbuk 580-185, Korea
  • Myung Woo Byun Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, Jeonbuk 580-185, Korea
  • Il Yun Jeong Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, Jeonbuk 580-185, Korea

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