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Enhancement of Anti-tumorigenic Polysaccharide Production, Adhesion, and Branch Formation of Bifidobacterium bifidum BGN4 by Phytic Acid

원문정보

Seockmo Ku, Hyun Ju You, Geun Eog Ji

한국식품과학회 Food Science and Biotechnology Volume 18 Number 3 2009.06 pp.749-754
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초록

영어

The polysaccharide (BB-pol) extracted from Bifidobacterium bifidum BGN4 showed growth inhibitory effects onseveral colon cancer cell lines such as HT-29 and HCT-116. To increase the yield of polysaccharide, B. bifidum BGN4 wascultured in various culture media with different compositions. When B. bifidum BGN4 was cultured in modified MRS brothcontaining phytic acid, the cells showed increased branch formation and enlarged morphology. The content of totalcarbohydrate and the ability of adhesion to intestinal epithelial cells were also increased by phytic acid. The polysaccharideobtained from the cells grown in the presence of phytic acid inhibited the proliferation of cancer cell lines such as HT-29 andMCF-7 cells but not normal colon cell line, FHC. Taken together, Bifidobacterium grown in the presence of phytic acid mayconfer enhanced beneficial function for the host.

목차

Abstract
 Introduction
 Materials and Methods
 Results and Discussion
 References

키워드

저자정보

  • Seockmo Ku Department of Food and Nutrition, Research Institute of Human Ecology, Seoul National University, Seoul 151-742, Korea
  • Hyun Ju You Department of Food and Nutrition, Research Institute of Human Ecology, Seoul National University, Seoul 151-742, Korea
  • Geun Eog Ji Department of Food and Nutrition, Research Institute of Human Ecology, Seoul National University, Seoul 151-742, Korea; Research Center, Bifido, Inc., Hongcheon, Gangwon 250-804, Korea

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