earticle

영어

This study investigated the proapoptotic effect of ethanol extracts obtained from dandelion (Taraxacum officinale)flower on human ovarian cancer SK-OV-3 cells. Cells were treated with dandelion flowers ethanol extract (DFE) ranging from1.5625 to 100µg/mL for 24hr. Significant antiproliferative effects of DFE were first observed from at 6.25µg/mL (p<0.05),and this inhibition showed in a dose-dependent manner. When cells were treated with more than 6.25µg/mL DFE, cell-cycleanalysis showed that DFE caused an increase in the percentage of sub-G0/G1 cells and arrested at the S and G2/M phase in adose-dependent manner. Moreover, apoptosis induction by DFE involved p53 activation and bax upregulation as well asdownregulation of bcl-2. Our findings indicate that DFE resulted in apoptotic cell death, suggesting that DFE possessespotential anticancer properties.