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The preventive effect of chewing gum containing maltitol, xylitol, gum base, and sugar on remineralization wereinvestigated. The clinical study consisted of 8 weeks’ randomized, double blind, controlled, cross-over clinical trials including24 healthy adults had chew gum. After each test week, remineralization effect was evaluated by measuring microhardness andscanning electron microscopy (SEM). Microhardness of experimental chewing gum containing maltitol or xylitol wassignificantly higher than that of sugar gum (p<0.005). Images of SEM showed the remineralization effect of gum containinggum base, maltitol, or xylitol compared with sugar gum. Maltitol and xylitol gums were more effective in remineralizationthan sugar gum. It was concluded that maltitol and xylitol can be used as sugar substitute to prevent dental caries.