원문정보
초록
영어
Phloroglucinol derivatives, dioxinodehydroeckol (1) and 1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4-dioxin (2), were isolated from Ecklonia Cava. Their abilities to inhibit proliferation of MCF-7 and MDA-MB-231 human breast cancer cells were evaluated by measuring cell death via induction of apoptosis. The compound 1 exerted a higher anti-proliferative activity in the human breast cancer cells compared with compound 2. Compound 1 induced significant proliferative inhibition and apoptosis in a dosedependent
manner in MCF-7 human cancer cells. Treatment with compound 1 induced the increase in caspase (-3 and -9) activities, DNA repair enzyme poly-(ADP-ribose) polymerase (PARP) cleavage, and pro-apoptotic gene and the decrease in anti-apoptotic gene. Besides, NF-κB family and -dependent activated genes were downregulated by compound 1. These results indicated that the potential inhibitory effect of compound 1 against growth of MCF-7 human
breast cancer cells might be associated with induction of apoptosis through NF-κB or -dependent pathway. Although further studies are needed, the present results suggest that compound 1 has a promising potential as valuable chemopreventive agents.