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The aim of this work was to prepare liposome containing vancomycin and propolis for topical delivery.The vancomycin and propolis were successfully encapsulated in phosphatidyl choline-based liposomes and the possible improvement of their antioxidant and antimicrobial activities was tested against selected microbial. Particles with regular morphology, mean diameter ranging 100nm to 300nm, and good entrapment efficiency for propolis were obtained. The in vitro antimicrobial activity of nanoparticles was evaluated against microorganism of MRSA (Methicillin-resistant Staphylococcus aureus) and MRSE (Methicillin-resistant Staphylococcus epidermidis). The percentage of the encapsulated propolis and vancomycin was determined by uv-vis spectrophotometer. In order to investigate any possible synergistic or antagonistic effect between propolis and vancomycin, the antimicrobial activities of the mixtures, were also determined before
and after encapsulation in liposomes. The antibiotics loaded liposomes can be used as a potential carrier for topical delivery.