원문정보
초록
영어
The objective of the present work was to develop a new drug nanocarrier consisting of nanoparticles made of glycol chitosan(Gc) and eicosapentaenoic acid (EPA). We describe EPA conjugated Gc self-assembled nanoparticles as a promising system for inhibit inflammation in keratinocytes. Gc-EPA formed self-assembled nanoparticles spherical shape and diameter of
approximately 100 nm by probe sonication in aqueous medium. EPA was loaded in to the Gc-EPA nanoparticles as a model drug. The chracteristics of EPA loaded Gc-EPA nanoparticles was analyzed using DLS, TEM and DSC. Their size increased from 250-450nm. The in vivo release behavior of EPA from Gc-EPA nanoparticles was studied by a dialysis method in
phosphate buffered saline. EPA loaded Gc-EPA nanoparticles are valuable to enhance the absorption of a poorly water soluble water.